Celebrex is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Celebrex works by reducing hormones that cause inflammation and pain in the body. Celebrex is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain. Celebrex is also used in the treatment of hereditary polyps in the colon. Celebrex may also be used for other purposes not listed in this medication guide.